{"id":16736,"date":"2025-12-15T19:16:56","date_gmt":"2025-12-15T19:16:56","guid":{"rendered":"https:\/\/each.ut.ee\/EACH\/?p=16736"},"modified":"2026-02-18T18:50:28","modified_gmt":"2026-02-18T18:50:28","slug":"our-lc-ms-validation-activities-at-the-iupac-dsm-lc-ms-validation-workshop","status":"publish","type":"post","link":"http:\/\/each.ut.ee\/EACH\/our-lc-ms-validation-activities-at-the-iupac-dsm-lc-ms-validation-workshop\/","title":{"rendered":"Our LC-MS validation activities at the IUPAC-DSM LC-MS validation workshop"},"content":{"rendered":"\n
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Riin Rebane, Asko Laaniste and Ivo Leito from the University of Tartu participated on 10-11.12.2025 in the Joint IUPAC-DSM Workshop on LC-MS method validation and performance<\/a>, organised jointly by the IUPAC\u2019s Division of Analytical Chemistry and the Mass spectrometry division (DSM) of the Italian Chemical Society.<\/strong><\/p>\n\n\n\n

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Riin presenting<\/figcaption><\/figure>\n\n\n\n

Riin presented the opening keynote of the event titled \u201cPrinciples of method validation<\/a>\u201d. Her presentation reframed LC-MS method validation as a risk-management process rather than a checklist of validation characteristics. By zooming out to the method\u2019s intended purpose, each validation characteristic is linked to the specific risks it is designed to control. This view allows to build evidence that the method performs reliably under real-world conditions and is truly fit for purpose and produces results with known confidence.<\/p>\n\n\n\n

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Ivo\u2019s talk \u201cWhat are the issues encountered in the real world? Lessons learned form an online validation course<\/a>\u201d presented an analysis of the main issues brought up by the participants of the nine editions of an online LC-MS method validation course (https:\/\/sisu.ut.ee\/lcms_method_validation\/<\/a>). The analysis of 2640 course forum posts and 336 participant feedback submissions revealed that practitioners struggle a lot with calculations and spreadsheet software, which diverts effort from real \u201canalytical hemistry\u201d issues.  <\/p>\n\n\n\n

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Asko leading the ValChrom session<\/figcaption><\/figure>\n\n\n\n

Asko’s session \u201cValChrom open-access online validation software<\/a>\u201d was a workshop in the true sense of the word: a hands-on session on the online validation software ValChrom<\/a> developed at UT. Participants had instant access to the software freely available in web and demo materials. Asko walked them through the whole process of ValChrom from start to finish, from defining analytes to customizing experimental plan with AI and finishing with automatically generated DOCX file with the whole validation data in it. ValChrom’s Design of Experiements (DoE) capabilities were also covered and it was nice to see that throughout the two days a big number of presentations also involved DoE one way or another, indicating a rising need for such tools.<\/p>\n\n\n\n

All in all, the contributions of our team were highly appreciated, indicated by numerous questions, both during sessions and (especially) during coffee breaks.<\/p>\n\n\n\n

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Riin Rebane, Asko Laaniste and Ivo Leito from the University of Tartu participated on 10-11.12.2025 in the Joint IUPAC-DSM Workshop on LC-MS method validation and performance, organised jointly by the IUPAC\u2019s Division of Analytical Chemistry and the Mass spectrometry division (DSM) of the Italian Chemical Society. Riin presented the opening keynote of the event titled […]<\/p>\n","protected":false},"author":23,"featured_media":16737,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-16736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"blocksy_meta":[],"_links":{"self":[{"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/16736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/comments?post=16736"}],"version-history":[{"count":5,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/16736\/revisions"}],"predecessor-version":[{"id":16853,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/16736\/revisions\/16853"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/media\/16737"}],"wp:attachment":[{"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/media?parent=16736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/categories?post=16736"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/tags?post=16736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}