{"id":14073,"date":"2021-03-17T17:30:26","date_gmt":"2021-03-17T17:30:26","guid":{"rendered":"http:\/\/each.ut.ee\/EACH\/?p=14073"},"modified":"2024-08-03T16:42:32","modified_gmt":"2024-08-03T16:42:32","slug":"aminoacridines-as-matrix-materials-for-the-analysis-of-complex-samples-in-maldi-ms","status":"publish","type":"post","link":"https:\/\/each.ut.ee\/EACH\/aminoacridines-as-matrix-materials-for-the-analysis-of-complex-samples-in-maldi-ms\/","title":{"rendered":"Aminoacridines as matrix materials for the analysis of complex samples in MALDI(-)-MS"},"content":{"rendered":"\n<p><strong>A highly interdisciplinary study ranging from computational chemistry to cultural heritage has now been published &#8211; <a href=\"https:\/\/doi.org\/10.1021\/jasms.1c00037\">Experimental and Computational Study of Aminoacridines as MALDI(-)-MS Matrix Materials for the Analysis of Complex Samples, <em>J. Am. Soc. Mass Spectrom.<\/em> 2021.<\/a>\u00a0\u00a0<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-1024x576.png\" alt=\"\" class=\"wp-image-14074\" width=\"447\" height=\"251\" srcset=\"https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-1024x576.png 1024w, https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-300x169.png 300w, https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021-768x432.png 768w, https:\/\/each.ut.ee\/EACH\/wp-content\/uploads\/2021\/03\/Blogpost-17032021.png 1266w\" sizes=\"auto, (max-width: 447px) 100vw, 447px\" \/><\/a><\/figure><\/div>\n\n\n\n<p>9-aminoacridine (9-AA) is a well-known matrix material used for the MALD(-)-MS analysis. Among the other monoaminoacridines (AAs), only 3-AA has been tested once (in our cultural heritage workgroup) but the suitability of the other AAs was unknown.<\/p>\n\n\n\n<p>To fill this gap, the capabilities of all five AAs were studied by analysing different materials (stearic acid, colophony resin, dyer&#8217;s madder, and a resinous sample from a 16th-century shipwreck). Also, a vast range of properties for these aminoacridines were experimentally or computationally characterized (including UV-Vis absorption and fluorescence spectra, proton transfer reactions, crystallization).&nbsp;<\/p>\n\n\n\n<p>The results demonstrated, that all the AAs are suitable for the MALDI(-)-MS analysis of these materials. Interestingly, 3-AA and 4-AA outperformed the other AAs (including the best-known 9-AA) and were the preferred matrices for the analysis of samples studied in this work.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A highly interdisciplinary study ranging from computational chemistry to cultural heritage has now been published &#8211; Experimental and Computational Study of Aminoacridines as MALDI(-)-MS Matrix Materials for the Analysis of Complex Samples, J. Am. Soc. Mass Spectrom. 2021.\u00a0\u00a0 9-aminoacridine (9-AA) is a well-known matrix material used for the MALD(-)-MS analysis. Among the other monoaminoacridines (AAs), [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":14074,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-14073","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/14073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/comments?post=14073"}],"version-history":[{"count":2,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/14073\/revisions"}],"predecessor-version":[{"id":14076,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/posts\/14073\/revisions\/14076"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/media\/14074"}],"wp:attachment":[{"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/media?parent=14073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/categories?post=14073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/each.ut.ee\/EACH\/wp-json\/wp\/v2\/tags?post=14073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}